3ull
From Proteopedia
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[[Image:3ull.gif|left|200px]] | [[Image:3ull.gif|left|200px]] | ||
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'''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN''' | '''HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN''' | ||
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[[Category: Urbanke, C.]] | [[Category: Urbanke, C.]] | ||
[[Category: Yang, C.]] | [[Category: Yang, C.]] | ||
| - | [[Category: | + | [[Category: Dna replication]] |
| - | [[Category: | + | [[Category: Dna-binding protein]] |
| - | [[Category: | + | [[Category: Mitochondrion]] |
| - | [[Category: | + | [[Category: Transit peptide]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:14:57 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:14, 4 May 2008
HUMAN MITOCHONDRIAL SINGLE-STRANDED DNA BINDING PROTEIN
Overview
We solved the crystal structure of the homotetrameric single-stranded DNA binding (SSB) protein from human mitochondria at a resolution of 2.4 A. The tetramer is formed by two dimers interacting head-to-head and shows D2 symmetry. Sequence-related tetrameric SSB proteins occur in prokaryotes and eukaryotic mitochondria; this is the first report of an atomic resolution structure of this type of protein. Using biochemical data and analysis of sequence homologies, we were able to correlate the functional properties with structure. We propose that ssDNA wraps around the tetrameric HsmtSSB protein through electropositive channels guided by flexible loops.
About this Structure
3ULL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution., Yang C, Curth U, Urbanke C, Kang C, Nat Struct Biol. 1997 Feb;4(2):153-7. PMID:9033597 Page seeded by OCA on Sun May 4 22:14:57 2008
