437d

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[[Image:437d.gif|left|200px]]
[[Image:437d.gif|left|200px]]
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{{Structure
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|PDB= 437d |SIZE=350|CAPTION= <scene name='initialview01'>437d</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_437d", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|DOMAIN=
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{{STRUCTURE_437d| PDB=437d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=437d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=437d OCA], [http://www.ebi.ac.uk/pdbsum/437d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=437d RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''
'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''
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==About this Structure==
==About this Structure==
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437D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA].
==Reference==
==Reference==
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10074948 10074948]
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10074948 10074948]
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[[Category: Protein complex]]
 
[[Category: Berger, J M.]]
[[Category: Berger, J M.]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]
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[[Category: Rich, A.]]
[[Category: Rich, A.]]
[[Category: Su, L.]]
[[Category: Su, L.]]
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[[Category: pseudoknot]]
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[[Category: Pseudoknot]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: triplex]]
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[[Category: Triplex]]
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[[Category: viral frameshifting]]
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[[Category: Viral frameshifting]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:16 2008''
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Revision as of 19:17, 4 May 2008

Image:437d.gif

Template:STRUCTURE 437d

CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING


Overview

Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.

About this Structure

Full crystallographic information is available from OCA.

Reference

Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:10074948 Page seeded by OCA on Sun May 4 22:17:47 2008

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