4aig

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[[Image:4aig.gif|left|200px]]
[[Image:4aig.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 4aig |SIZE=350|CAPTION= <scene name='initialview01'>4aig</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_4aig", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLX:N-[(FURAN-2-YL)CARBONYL]-(S)-LEUCYL-(R)-[1-AMINO-2(1H-INDOL-3-YL)ETHYL]-PHOSPHONIC+ACID'>FLX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_4aig| PDB=4aig | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aig OCA], [http://www.ebi.ac.uk/pdbsum/4aig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4aig RCSB]</span>
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}}
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'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''
'''ADAMALYSIN II WITH PHOSPHONATE INHIBITOR'''
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[[Category: Mazza, F.]]
[[Category: Mazza, F.]]
[[Category: Pochetti, G.]]
[[Category: Pochetti, G.]]
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[[Category: snake venom metalloendopeptidase]]
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[[Category: Snake venom metalloendopeptidase]]
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[[Category: zinc protease]]
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[[Category: Zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:20:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:51 2008''
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Revision as of 19:20, 4 May 2008

Image:4aig.gif

Template:STRUCTURE 4aig

ADAMALYSIN II WITH PHOSPHONATE INHIBITOR


Overview

The search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II, a member of the reprolysin family, and a phosphonate inhibitor modeled on an endogenous venom tripeptide. The inhibitor occupies the primed region of the cleavage site adopting a retro-binding mode. The phosphonate group ligates the zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S1'. An adamalysin-based model of tumor necrosis factor-alpha-converting enzyme (TACE) reveals a smaller S1' pocket for this enzyme.

About this Structure

4AIG is a Single protein structure of sequence from Crotalus adamanteus. Full crystallographic information is available from OCA.

Reference

2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode., Cirilli M, Gallina C, Gavuzzo E, Giordano C, Gomis-Ruth FX, Gorini B, Kress LF, Mazza F, Paradisi MP, Pochetti G, Politi V, FEBS Lett. 1997 Dec 1;418(3):319-22. PMID:9428736 Page seeded by OCA on Sun May 4 22:20:29 2008

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