4hvp

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[[Image:4hvp.gif|left|200px]]
[[Image:4hvp.gif|left|200px]]
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{{Structure
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|PDB= 4hvp |SIZE=350|CAPTION= <scene name='initialview01'>4hvp</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_4hvp", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>
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{{STRUCTURE_4hvp| PDB=4hvp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvp OCA], [http://www.ebi.ac.uk/pdbsum/4hvp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4hvp RCSB]</span>
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'''STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A STUBTRATE-BASED INHIBITOR AT 2.3 ANGSTROMS RESOLUTION'''
'''STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A STUBTRATE-BASED INHIBITOR AT 2.3 ANGSTROMS RESOLUTION'''
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[[Category: Toth, M V.]]
[[Category: Toth, M V.]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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[[Category: hydrolase(acid proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:25:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:05 2008''
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Revision as of 19:25, 4 May 2008

Image:4hvp.gif

Template:STRUCTURE 4hvp

STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A STUBTRATE-BASED INHIBITOR AT 2.3 ANGSTROMS RESOLUTION


Overview

The structure of a complex between a peptide inhibitor with the sequence N-acetyl-Thr-Ile-Nle-psi[CH2-NH]-Nle-Gln-Arg.amide (Nle, norleucine) with chemically synthesized HIV-1 (human immunodeficiency virus 1) protease was determined at 2.3 A resolution (R factor of 0.176). Despite the symmetric nature of the unliganded enzyme, the asymmetric inhibitor lies in a single orientation and makes extensive interactions at the interface between the two subunits of the homodimeric protein. Compared with the unliganded enzyme, the protein molecule underwent substantial changes, particularly in an extended region corresponding to the "flaps" (residues 35 to 57 in each chain), where backbone movements as large as 7 A are observed.

About this Structure

4HVP is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution., Miller M, Schneider J, Sathyanarayana BK, Toth MV, Marshall GR, Clawson L, Selk L, Kent SB, Wlodawer A, Science. 1989 Dec 1;246(4934):1149-52. PMID:2686029 Page seeded by OCA on Sun May 4 22:25:24 2008

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