4i1b

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[[Image:4i1b.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1b OCA], [http://www.ebi.ac.uk/pdbsum/4i1b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4i1b RCSB]</span>
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'''FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE'''
'''FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE'''
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[[Category: Svensson, L A.]]
[[Category: Svensson, L A.]]
[[Category: Veerapandian, B.]]
[[Category: Veerapandian, B.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:25:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:07 2008''
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Revision as of 19:25, 4 May 2008

Image:4i1b.jpg

Template:STRUCTURE 4i1b

FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE


Overview

The molecular structure of interleukin-1 beta, a hormone-like cytokine with roles in several disease processes, has been determined at 2.0 A resolution and refined to a crystallographic R-factor of 0.19. The framework of this molecule consists of 12 antiparallel beta-strands exhibiting pseudo-3-fold symmetry. Six of the strands make up a beta-barrel with polar residues concentrated at either end. Analysis of the three-dimensional structure, together with results from site-directed mutagenesis and biochemical and immunological studies, suggest that the core of the beta-barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL-1 interacts with its receptor.

About this Structure

4I1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Functional implications of interleukin-1 beta based on the three-dimensional structure., Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL, Proteins. 1992 Jan;12(1):10-23. PMID:1553379 Page seeded by OCA on Sun May 4 22:25:31 2008

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