4mt2

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[[Image:4mt2.gif|left|200px]]
[[Image:4mt2.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_4mt2", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_4mt2| PDB=4mt2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt2 OCA], [http://www.ebi.ac.uk/pdbsum/4mt2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4mt2 RCSB]</span>
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'''COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2'''
'''COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2'''
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[[Category: Robbins, A H.]]
[[Category: Robbins, A H.]]
[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
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[[Category: metallothionein]]
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[[Category: Metallothionein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:27:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:30 2008''
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Revision as of 19:27, 4 May 2008

Image:4mt2.gif

Template:STRUCTURE 4mt2

COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2


Overview

Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. & Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.

About this Structure

4MT2 is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2., Braun W, Vasak M, Robbins AH, Stout CD, Wagner G, Kagi JH, Wuthrich K, Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8. PMID:1438200 Page seeded by OCA on Sun May 4 22:27:00 2008

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