4tmy

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[[Image:4tmy.jpg|left|200px]]
[[Image:4tmy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 4tmy |SIZE=350|CAPTION= <scene name='initialview01'>4tmy</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_4tmy", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACA:Active+Site+And+Metal+Binding+Site'>ACA</scene> and <scene name='pdbsite=ACB:Active+Site+And+Metal+Binding+Site'>ACB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CHEY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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-->
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|DOMAIN=
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{{STRUCTURE_4tmy| PDB=4tmy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmy OCA], [http://www.ebi.ac.uk/pdbsum/4tmy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4tmy RCSB]</span>
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}}
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'''CHEY FROM THERMOTOGA MARITIMA (MG-IV)'''
'''CHEY FROM THERMOTOGA MARITIMA (MG-IV)'''
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[[Category: Remington, S J.]]
[[Category: Remington, S J.]]
[[Category: Usher, K C.]]
[[Category: Usher, K C.]]
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[[Category: chemotaxis]]
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[[Category: Chemotaxis]]
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[[Category: magnesium binding]]
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[[Category: Magnesium binding]]
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[[Category: phosphoryl transfer]]
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[[Category: Phosphoryl transfer]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:30:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:40:25 2008''
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Revision as of 19:30, 4 May 2008

Image:4tmy.jpg

Template:STRUCTURE 4tmy

CHEY FROM THERMOTOGA MARITIMA (MG-IV)


Overview

The crystal structure of CheY protein from Thermotoga maritima has been determined in four crystal forms with and without Mg++ bound, at up to 1.9 A resolution. Structural comparisons with CheY from Escherichia coli shows substantial similarity in their folds, with some concerted changes propagating away from the active site that suggest how phosphorylated CheY, a signal transduction protein in bacterial chemotaxis, is recognized by its targets. A highly conserved segment of the protein (the "y-turn loop," residues 55-61), previously suggested to be a rigid recognition determinant, is for the first time seen in two alternative conformations in the different crystal structures. Although CheY from Thermotoga has much higher thermal stability than its mesophilic counterparts, comparison of structural features previously proposed to enhance thermostability such as hydrogen bonds, ion pairs, compactness, and hydrophobic surface burial would not suggest it to be so.

About this Structure

4TMY is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability., Usher KC, de la Cruz AF, Dahlquist FW, Swanson RV, Simon MI, Remington SJ, Protein Sci. 1998 Feb;7(2):403-12. PMID:9521117 Page seeded by OCA on Sun May 4 22:30:20 2008

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