5fit

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[[Image:5fit.gif|left|200px]]
[[Image:5fit.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 5fit |SIZE=350|CAPTION= <scene name='initialview01'>5fit</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_5fit", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AVE:Active+Site+HIS+Responsible+For+Forming+The+Transient+Nu+...'>AVE</scene> and <scene name='pdbsite=HNE:HIS+Triad+For+Which+This+Family+Was+Named'>HNE</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AP2:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>AP2</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-adenosyl)-triphosphatase Bis(5'-adenosyl)-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.29 3.6.1.29] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FHIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_5fit| PDB=5fit | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fit OCA], [http://www.ebi.ac.uk/pdbsum/5fit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5fit RCSB]</span>
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}}
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'''FHIT-SUBSTRATE ANALOG'''
'''FHIT-SUBSTRATE ANALOG'''
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==Reference==
==Reference==
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9323207 9323207]
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9323207 9323207]
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[[Category: Bis(5'-adenosyl)-triphosphatase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Klein, M G.]]
[[Category: Klein, M G.]]
[[Category: Lima, C D.]]
[[Category: Lima, C D.]]
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[[Category: fhit]]
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[[Category: Fhit]]
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[[Category: fragile histidine triad protein]]
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[[Category: Fragile histidine triad protein]]
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[[Category: histidine triad protein family]]
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[[Category: Histidine triad protein family]]
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[[Category: hit protein family]]
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[[Category: Hit protein family]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: nucleotidyl hydrolase]]
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[[Category: Nucleotidyl hydrolase]]
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[[Category: nucleotidyl transferase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: putative tumor suppressor]]
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[[Category: Putative tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:34:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:23 2008''
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Revision as of 19:34, 4 May 2008

Image:5fit.gif

Template:STRUCTURE 5fit

FHIT-SUBSTRATE ANALOG


Overview

The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.

About this Structure

5FIT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207 Page seeded by OCA on Sun May 4 22:34:07 2008

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