6cmh

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[[Image:6cmh.gif|left|200px]]
[[Image:6cmh.gif|left|200px]]
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{{Structure
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|PDB= 6cmh |SIZE=350|CAPTION= <scene name='initialview01'>6cmh</scene>
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The line below this paragraph, containing "STRUCTURE_6cmh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_6cmh| PDB=6cmh | SCENE= }}
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|RELATEDENTRY=[[3cmh|3CMH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cmh OCA], [http://www.ebi.ac.uk/pdbsum/6cmh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6cmh RCSB]</span>
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}}
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'''SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST'''
'''SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST'''
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==About this Structure==
==About this Structure==
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6CMH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMH OCA].
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6CMH is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMH OCA].
==Reference==
==Reference==
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[[Category: Ramage, R.]]
[[Category: Ramage, R.]]
[[Category: Sadler, I H.]]
[[Category: Sadler, I H.]]
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[[Category: endothelin-1]]
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[[Category: Endothelin-1]]
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[[Category: vasoconstrictor]]
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[[Category: Vasoconstrictor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:39:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:42:44 2008''
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Revision as of 19:39, 4 May 2008

Image:6cmh.gif

Template:STRUCTURE 6cmh

SYNTHETIC LINEAR MODIFIED ENDOTHELIN-1 AGONIST


Overview

The solution structure of a biologically active modified linear endothelin-1 analogue, ET1-21[Cys(Acm)1,15, Aib3,11, Leu7], has been determined for the first time by two-dimensional nuclear magnetic resonance spectroscopy in a methanol-d3/water solvent mixture. Out of approximately one hundred linear peptide analogues tested by biological assay, this peptide, together with a dozen others, showed significant ETB selective agonist activity. Here we report the solution structure of an ETB selective agonist of a full-length, synthetic linear endothelin analogue. The calculated structures indicate that the peptide adopts an alpha-helical conformation between residues Ser5-His16, whilst both N- and C-termini show no preferred conformation. These results suggest that the disulphide bridges normally associated with endothelin and sarafotoxin peptides may not necessarily be important for either ETB receptor binding activity or the formation of a helical conformation in solution.

About this Structure

6CMH is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling., Hewage CM, Jiang L, Parkinson JA, Ramage R, Sadler IH, J Pept Res. 1999 Mar;53(3):223-33. PMID:10231710 Page seeded by OCA on Sun May 4 22:39:40 2008

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