1b1v
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(New page: 200px<br /><applet load="1b1v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b1v" /> '''NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADIN...)
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Revision as of 09:09, 20 November 2007
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NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS
Overview
The structure of the recently identified plasmatocyte spreading peptide, from the moth Pseudoplusia includens (PSP1) has been determined by NMR, spectroscopy. This novel insect cytokine consists of 23 amino acid, residues and a single disulfide bond. Torsion angle dynamics calculations, utilizing a total of 337 distance constraints yielded an ensemble of 30, structures with an average backbone root mean square deviation for, residues 7-22 of 0.18 A from the mean structure. The structure consists of, a disordered N-terminal region and a well defined core that is stabilized, by numerous hydrophobic interactions and a short beta-hairpin. Structural, comparisons confirm that PSP1 adopts an epidermal growth factor (EGF)-like, fold with close similarity to the C-terminal subdomain of EGF-like module, 5 of human thrombomodulin. The combination of the three-dimensional, structure of PSP1 and the extensive literature on EGF-receptor, interactions should accelerate the process of identifying the specific, residues responsible for receptor binding activity of this family of, immunoregulatory peptides.
About this Structure
1B1V is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens., Volkman BF, Anderson ME, Clark KD, Hayakawa Y, Strand MR, Markley JL, J Biol Chem. 1999 Feb 19;274(8):4493-6. PMID:9988679
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