7ins

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[[Image:7ins.gif|left|200px]]
[[Image:7ins.gif|left|200px]]
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{{Structure
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|PDB= 7ins |SIZE=350|CAPTION= <scene name='initialview01'>7ins</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_7ins", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=MCR:M-Cresol+Binding+Site.+Oh+Binds+On+Each+Monomer+To+Oa6+A+...'>MCR</scene>
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|LIGAND= <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_7ins| PDB=7ins | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7ins FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ins OCA], [http://www.ebi.ac.uk/pdbsum/7ins PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=7ins RCSB]</span>
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}}
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'''STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z'''
'''STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z'''
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[[Category: Hansen, F B.]]
[[Category: Hansen, F B.]]
[[Category: Korber, F.]]
[[Category: Korber, F.]]
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[[Category: hormone]]
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[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:46:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:44:23 2008''
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Revision as of 19:46, 4 May 2008

Image:7ins.gif

Template:STRUCTURE 7ins

STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z


Overview

The crystal structure of NPH-insulin, pig insulin cocrystallized with zinc, m-cresol and protamine, has been solved by molecular replacement and refined using restrained least-squares refinement methods. The final crystallographic R factor for all reflections between 2 and 10 A is 19.4%. The insulin molecules are arranged as hexamers with two tetrahedrally coordinated Zn atoms in the central channel and one m-cresol bound to each monomer near His B5. One protamine binding site has been unequivocally identified near a dimer-dimer interface, although most of the polypeptide is crystallographically disordered. The conformation of the insulin moiety and the structural differences between the three unique monomers have been analysed. The zinc and m-cresol environments are described and the nature of the protamine binding site is outlined.

About this Structure

7INS is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of porcine insulin cocrystallized with clupeine Z., Balschmidt P, Hansen FB, Dodson EJ, Dodson GG, Korber F, Acta Crystallogr B. 1991 Dec 1;47 ( Pt 6):975-86. PMID:1772633 Page seeded by OCA on Sun May 4 22:46:20 2008

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