9ant

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[[Image:9ant.gif|left|200px]]
[[Image:9ant.gif|left|200px]]
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{{Structure
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|PDB= 9ant |SIZE=350|CAPTION= <scene name='initialview01'>9ant</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_9ant", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
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{{STRUCTURE_9ant| PDB=9ant | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=9ant FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ant OCA], [http://www.ebi.ac.uk/pdbsum/9ant PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=9ant RCSB]</span>
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'''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX'''
'''ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX'''
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[[Category: Fraenkel, E.]]
[[Category: Fraenkel, E.]]
[[Category: Pabo, C O.]]
[[Category: Pabo, C O.]]
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[[Category: complex (homeodomain/dna)]]
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[[Category: Dna-binding protein]]
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[[Category: dna-binding protein]]
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[[Category: Homeodomain]]
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[[Category: homeodomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:52:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:45:57 2008''
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Revision as of 19:52, 4 May 2008

Image:9ant.gif

Template:STRUCTURE 9ant

ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX


Overview

Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.

About this Structure

9ANT is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex., Fraenkel E, Pabo CO, Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:9699632 Page seeded by OCA on Sun May 4 22:52:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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