9hvp

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[[Image:9hvp.gif|left|200px]]
[[Image:9hvp.gif|left|200px]]
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{{Structure
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|PDB= 9hvp |SIZE=350|CAPTION= <scene name='initialview01'>9hvp</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_9hvp", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=COR:2,4-DIAMINO-1,5-DIPHENYL-3-HYDROXYPENTANE'>COR</scene>, <scene name='pdbligand=PHQ:FORMIC+ACID+BENZYL+ESTER'>PHQ</scene>
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{{STRUCTURE_9hvp| PDB=9hvp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=9hvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hvp OCA], [http://www.ebi.ac.uk/pdbsum/9hvp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=9hvp RCSB]</span>
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'''DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE'''
'''DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE'''
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[[Category: Erickson, J.]]
[[Category: Erickson, J.]]
[[Category: Neidhart, D J.]]
[[Category: Neidhart, D J.]]
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[[Category: hydrolase(acid proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:53:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:46:07 2008''
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Revision as of 19:53, 4 May 2008

Image:9hvp.gif

Template:STRUCTURE 9hvp

DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE


Overview

A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and acute HIV-1 infection in vitro, was at least 10,000-fold more potent against HIV-1 protease than against related enzymes, and appeared to be stable to degradative enzymes. The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion.

About this Structure

9HVP is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease., Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al., Science. 1990 Aug 3;249(4968):527-33. PMID:2200122 Page seeded by OCA on Sun May 4 22:53:07 2008

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