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1b7f

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(New page: 200px<br /><applet load="1b7f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b7f, resolution 2.6&Aring;" /> '''SXL-LETHAL PROTEIN/RN...)
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Revision as of 09:18, 20 November 2007

Image:1b7f.gif

1b7f, resolution 2.6Å

Drag the structure with the mouse to rotate

SXL-LETHAL PROTEIN/RNA COMPLEX

Overview

The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates, alternative splicing of the transformer (tra) messenger RNA precursor by, binding to the tra polypyrimidine tract during the sex-determination, process. The crystal structure has now been determined at 2.6 A resolution, of the complex formed between two tandemly arranged RNA-binding domains of, the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the, tra polypyrimidine tract. The two RNA-binding domains have their, beta-sheet platforms facing each other to form a V-shaped cleft. The RNA, is characteristically extended and bound in this cleft, where the, UGUUUUUUU sequence is specifically recognized by the protein. This, structure offers the first insight, to our knowledge, into how a protein, binds specifically to a cognate RNA without any intramolecular, base-pairing.

About this Structure

1B7F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141

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