1b8q
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(New page: 200px<br /><applet load="1b8q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b8q" /> '''SOLUTION STRUCTURE OF THE EXTENDED NEURONAL ...)
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Revision as of 09:20, 20 November 2007
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SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE
Overview
The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a, scaffold for organizing the signal transduction complex of the enzyme. The, NMR structure of a complex composed of the nNOS PDZ domain and an, associated peptide suggests that a two-stranded beta-sheet C-terminal to, the canonical PDZ domain may mediate its interaction with the PDZ domains, of postsynaptic density-95 and alpha-syntrophin. The structure also, provides the molecular basis of recognition of Asp-X-Val-COOH peptides by, the nNOS PDZ domain. The role of the C-terminal extension in, Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies, further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from, a novel cytosolic protein named CAPON bind to the same pocket of the nNOS, PDZ domain.
About this Structure
1B8Q is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide., Tochio H, Zhang Q, Mandal P, Li M, Zhang M, Nat Struct Biol. 1999 May;6(5):417-21. PMID:10331866
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