1bax
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(New page: 200px<br /><applet load="1bax" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bax" /> '''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NM...)
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Revision as of 09:23, 20 November 2007
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MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE
Overview
The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D, retroviruses. In type B and D retroviruses, the Gag protein pre-assembles, before association with the membrane, whereas in type C retroviruses, (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma, membrane, where the particle formation occurs. The N-terminal domain of, Gag, the matrix protein (MA), plays a critical role in determining this, morphogenic difference. We have determined the three-dimensional solution, structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The, protein contains four alpha-helices that are structurally similar to the, known type C MA structures. This similarity implies possible common, assembly units and membrane-binding mechanisms for type C and B/D, retroviruses. In addition to this, the interpretation of mutagenesis data, has enabled us to identify, for the first time, the structural basis of a, putative intracellular targeting motif.
About this Structure
1BAX is a Single protein structure of sequence from Simian mason-pfizer virus. This structure superseeds the now removed PDB entry 1AT7. Full crystallographic information is available from OCA.
Reference
The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly., Conte MR, Klikova M, Hunter E, Ruml T, Matthews S, EMBO J. 1997 Oct 1;16(19):5819-26. PMID:9312040
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