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1akd

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(New page: 200px<br /> <applet load="1akd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1akd, resolution 1.8&Aring;" /> '''CYTOCHROME P450CAM F...)
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Revision as of 17:21, 29 October 2007

Image:1akd.gif

1akd, resolution 1.8Å

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CYTOCHROME P450CAM FROM PSEUDOMONAS PUTIDA, COMPLEXED WITH 1S-CAMPHOR

Overview

The crystal structure of cytochrome P-450cam complexed with the enantiomer, (1S)-camphor has been solved to 1.8 angstroms resolution and compared with, the structure of the (1R)-camphor P-450cam complex. The overall protein, structure is the same for both enantiomer complexes. However, the, orientation of the substrates in the heme pocket differs. In contrast to, (1R)-camphor, the (1S)-enantiomer binds in at least two orientations. The, major binding mode of (1S)-camphor resembles the one of the, (1R)-enantiomer in that there is a hydrogen bond between Tyr-96 and the, quinone group of camphor, and the 10-methyl group points towards the, I-helix. The binding differs in that C-5 is not at a position suitable for, hydroxylation. In the other orientation (1S)-camphor is not hydrogen, bonded, ... [(full description)]

About this Structure

1AKD is a [Single protein] structure of sequence from [Pseudomonas putida] with K, HEM and CAM as [ligands]. Active as [[1]], with EC number [1.14.15.1]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of cytochrome P-450cam complexed with the (1S)-camphor enantiomer., Schlichting I, Jung C, Schulze H, FEBS Lett. 1997 Oct 6;415(3):253-7. PMID:9357977

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