3cgo

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Revision as of 06:55, 4 June 2008

Image:3cgo.jpg

Template:STRUCTURE 3cgo

IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding


Overview

A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis and chemical analogue SAR.

About this Structure

3CGO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding., Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V, Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. Epub 2008 Apr 22. PMID:18482836 Page seeded by OCA on Wed Jun 4 09:55:15 2008

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