1bvp
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(New page: 200px<br /><applet load="1bvp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bvp, resolution 2.6Å" /> '''THE CRYSTAL STRUCTURE...)
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Revision as of 09:50, 20 November 2007
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THE CRYSTAL STRUCTURE OF BLUETONGUE VIRUS VP7
Overview
Bluetongue virus (BTV), a representative of the orbivirus genus of the, Reoviridae, is considerably larger (at 80 nm across), and structurally, more complex, than any virus for which we have comprehensive structural, information. Orbiviruses infect mammalian hosts through insect vectors and, cause economically important diseases of domesticated animals. They, possess a segmented double-stranded RNA genome within a capsid composed of, four major types of polypeptide chains. An outer layer of VP2 and VP5 is, removed as the virus enters the target cell, to leave an intact core, within the cell. This core is 70 nm across and composed of 780 copies of, VP7 (M(r) 38K) that, as trimers, form 260 'bristly' capsomeres clothing an, inner scaffold constructed from VP3 (M(r) 103K). We report here the, crystal structure of VP7 from BTV serotype 10, which reveals a molecular, architecture not seen previously in viral structural proteins. Each, subunit consists of two domains, one a beta-sandwich, the other a bundle, of alpha-helices, and a short carboxy-terminal arm which might tie trimers, together during capsid formation. A concentration of methionine residues, at the core of the molecule could provide plasticity, relieving structural, mismatches during assembly.
About this Structure
1BVP is a Single protein structure of sequence from Bluetongue virus 10 (isolate usa). Full crystallographic information is available from OCA.
Reference
The crystal structure of bluetongue virus VP7., Grimes J, Basak AK, Roy P, Stuart D, Nature. 1995 Jan 12;373(6510):167-70. PMID:7816101
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