1hjk

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(New page: 200px<br /> <applet load="1hjk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hjk, resolution 2.3&Aring;" /> '''ALKALINE PHOSPHATASE...)
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Revision as of 17:23, 29 October 2007

Image:1hjk.gif

1hjk, resolution 2.3Å

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ALKALINE PHOSPHATASE MUTANT H331Q

Overview

Using a mutant version of E. coli alkaline phosphatase, we succeeded in, trapping and determining the structure of the phospho-enzyme intermediate., The X-ray structure also revealed the catalytic water molecule, bound to, one of the active site zinc ions, positioned ideally for the apical attack, necessary for the hydrolysis of the intermediate.

About this Structure

1HJK is a [Single protein] structure of sequence from [Escherichia coli] with ZN, MG and SO4 as [ligands]. Active as [[1]], with EC number [3.1.3.1]. Full crystallographic information is available from [OCA].

Reference

Trapping and visualization of a covalent enzyme-phosphate intermediate., Murphy JE, Stec B, Ma L, Kantrowitz ER, Nat Struct Biol. 1997 Aug;4(8):618-22. PMID:9253408

Page seeded by OCA on Mon Oct 29 19:28:31 2007

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