1bz9

From Proteopedia

Revision as of 09:55, 20 November 2007

CRYSTAL STRUCTURE OF MURINE CLASS I MHC H2-DB COMPLEXED WITH A SYNTHETIC PEPTIDE P1027

Overview

The T cell receptor (TCR), from a xeno-reactive murine cytotoxic T, lymphocyte clone AHIII12.2, recognizes murine H-2Db complexed with peptide, p1027 (FAPGVFPYM), as well as human HLA-A2.1 complexed with peptide p1049, (ALWGFFPVL). A commonly proposed model (the molecular mimicry model) used, to explain TCR cross-reactivity suggests that the molecular surfaces of, the recognized complexes are similar in shape, charge, or both, in spite, of the primary sequence differences. To examine the mechanism of, xeno-reactivity of AHIII12.2, we have determined the crystal structures of, A2/p1049 and Db/p1027 to 2.5 A and 2.8 A resolution, respectively. The, crystal structures show that the TCR footprint regions of the two class I, complexes are significantly different in shape and charge. We propose that, rather than simple molecular mimicry, unpredictable arrays of common and, differential contacts on the two class I complexes are used for their, recognition by the same TCR.

About this Structure

1BZ9 is a Protein complex structure of sequences from Mus musculus. This structure superseeds the now removed PDB entry 1A9D. Full crystallographic information is available from OCA.

Reference

Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry., Zhao R, Loftus DJ, Appella E, Collins EJ, J Exp Med. 1999 Jan 18;189(2):359-70. PMID:9892618

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