2vpd
From Proteopedia
(New page: '''Unreleased structure''' The entry 2vpd is ON HOLD until Paper Publication Authors: Fiedler, M., Sanchez-Barrena, M.J., Nekrasov, M., Mieszczanek, J., Rybin, V., Muller, J., Bienz, M....) |
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| - | + | [[Image:2vpd.jpg|left|200px]] | |
| - | The | + | <!-- |
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| + | {{STRUCTURE_2vpd| PDB=2vpd | SCENE= }} | ||
| - | + | '''DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX''' | |
| - | Description: Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex | ||
| + | ==Overview== | ||
| + | Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of beta-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). The crystal structures of ternary complexes between PHD, HD1, and two different H3K4me peptides reveal a unique mode of histone tail recognition: efficient histone binding requires HD1 association, and the PHD-HD1 complex binds preferentially to H3K4me2 while displaying insensitivity to methylation of H3R2. Therefore, this is a prime example of histone tail binding by a PHD finger (of Pygo) being modulated by a cofactor (BCL9/Legless). Rescue experiments in Drosophila indicate that Wnt signaling outputs depend on histone decoding. The specificity of this process provided by the Pygo-BCL9/Legless complex suggests that this complex facilitates an early step in the transition from gene silence to Wnt-induced transcription. | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun | + | ==About this Structure== |
| + | 2VPD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPD OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex., Fiedler M, Sanchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Muller J, Evans P, Bienz M, Mol Cell. 2008 May 23;30(4):507-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18498752 18498752] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Protein complex]] | ||
| + | [[Category: Bienz, M.]] | ||
| + | [[Category: Evans, P.]] | ||
| + | [[Category: Fiedler, M.]] | ||
| + | [[Category: Mieszczanek, J.]] | ||
| + | [[Category: Muller, J.]] | ||
| + | [[Category: Nekrasov, M.]] | ||
| + | [[Category: Rybin, V.]] | ||
| + | [[Category: Sanchez-Barrena, M J.]] | ||
| + | [[Category: Bcl9 hd1 domain]] | ||
| + | [[Category: Chromosomal rearrangement]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Histone h3k4me2]] | ||
| + | [[Category: Hpygo1 phd domain]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Proto-oncogene]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signaling complex]] | ||
| + | [[Category: Wnt signaling pathway]] | ||
| + | [[Category: Zinc]] | ||
| + | [[Category: Zinc-finger]] | ||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:05:27 2008'' | ||
Revision as of 09:05, 18 June 2008
DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX
Overview
Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of beta-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). The crystal structures of ternary complexes between PHD, HD1, and two different H3K4me peptides reveal a unique mode of histone tail recognition: efficient histone binding requires HD1 association, and the PHD-HD1 complex binds preferentially to H3K4me2 while displaying insensitivity to methylation of H3R2. Therefore, this is a prime example of histone tail binding by a PHD finger (of Pygo) being modulated by a cofactor (BCL9/Legless). Rescue experiments in Drosophila indicate that Wnt signaling outputs depend on histone decoding. The specificity of this process provided by the Pygo-BCL9/Legless complex suggests that this complex facilitates an early step in the transition from gene silence to Wnt-induced transcription.
About this Structure
2VPD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex., Fiedler M, Sanchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Muller J, Evans P, Bienz M, Mol Cell. 2008 May 23;30(4):507-18. PMID:18498752 Page seeded by OCA on Wed Jun 18 12:05:27 2008
Categories: Homo sapiens | Protein complex | Bienz, M. | Evans, P. | Fiedler, M. | Mieszczanek, J. | Muller, J. | Nekrasov, M. | Rybin, V. | Sanchez-Barrena, M J. | Bcl9 hd1 domain | Chromosomal rearrangement | Gene regulation | Histone h3k4me2 | Hpygo1 phd domain | Metal-binding | Nucleus | Phosphoprotein | Proto-oncogene | Signaling protein | Wnt signaling complex | Wnt signaling pathway | Zinc | Zinc-finger
