3cl3
From Proteopedia
(New page: '''Unreleased structure''' The entry 3cl3 is ON HOLD until Paper Publication Authors: Bagneris, C., Ageichik, A.V., Cronin, N., Boshoff, C., Waksman, G., Barrett, T. Description: Cryst...) |
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| + | {{STRUCTURE_3cl3| PDB=3cl3 | SCENE= }} | ||
| - | + | '''Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome''' | |
| - | Description: Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome | ||
| + | ==Overview== | ||
| + | Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP (produced by the Kaposi's sarcoma herpes virus [KSHV]), which associates with IKKgamma, an essential component of the IKK complex or signalosome. This interaction renders the canonical NF-kappaB pathway constitutively active and has been linked to Kaposi's sarcoma and other malignancies. In order to elucidate the molecular basis underpinning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of a complex involving a fragment of IKKgamma bound to ks-vFLIP at 3.2 A. In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID). | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun | + | ==About this Structure== |
| + | 3CL3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL3 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome., Bagneris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T, Mol Cell. 2008 Jun 6;30(5):620-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18538660 18538660] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human herpesvirus 8]] | ||
| + | [[Category: Protein complex]] | ||
| + | [[Category: Ageichik, A V.]] | ||
| + | [[Category: Bagneris, C.]] | ||
| + | [[Category: Barrett, T.]] | ||
| + | [[Category: Boshoff, C.]] | ||
| + | [[Category: Cronin, N.]] | ||
| + | [[Category: Waksman, G.]] | ||
| + | [[Category: Coiled coil]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Cytoplasm]] | ||
| + | [[Category: Death effector domain]] | ||
| + | [[Category: Disease mutation]] | ||
| + | [[Category: Ectodermal dysplasia]] | ||
| + | [[Category: Host-virus interaction]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription regulation]] | ||
| + | [[Category: Viral protein/signaling protein complex]] | ||
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:10:46 2008'' | ||
Revision as of 09:10, 18 June 2008
Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome
Overview
Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP (produced by the Kaposi's sarcoma herpes virus [KSHV]), which associates with IKKgamma, an essential component of the IKK complex or signalosome. This interaction renders the canonical NF-kappaB pathway constitutively active and has been linked to Kaposi's sarcoma and other malignancies. In order to elucidate the molecular basis underpinning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of a complex involving a fragment of IKKgamma bound to ks-vFLIP at 3.2 A. In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID).
About this Structure
3CL3 is a Protein complex structure of sequences from Homo sapiens and Human herpesvirus 8. Full crystallographic information is available from OCA.
Reference
Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome., Bagneris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T, Mol Cell. 2008 Jun 6;30(5):620-31. PMID:18538660 Page seeded by OCA on Wed Jun 18 12:10:46 2008
Categories: Homo sapiens | Human herpesvirus 8 | Protein complex | Ageichik, A V. | Bagneris, C. | Barrett, T. | Boshoff, C. | Cronin, N. | Waksman, G. | Coiled coil | Coiled-coil | Cytoplasm | Death effector domain | Disease mutation | Ectodermal dysplasia | Host-virus interaction | Nucleus | Transcription | Transcription regulation | Viral protein/signaling protein complex
