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2k1a
From Proteopedia
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'''Bicelle-embedded integrin alpha(IIB) transmembrane segment''' | '''Bicelle-embedded integrin alpha(IIB) transmembrane segment''' | ||
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| + | ==Overview== | ||
| + | Integrin cell-adhesion receptors transduce signals bidirectionally across the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit. While the beta3 transmembrane segment consists of a linear 29-residue alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-helix (Ile-966 -Lys-989) followed by a backbone reversal that packs Phe-992-Phe-993 against the transmembrane helix. The length of the alphaIIb transmembrane helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering beta3 subunit. Sequence alignment shows Gly-991-Phe-993 to be fully conserved among all 18 human integrin alpha subunits, suggesting that their unusual structural motif is prototypical for integrin alpha subunits. The alphaIIb transmembrane structure demonstrates a level of complexity within the membrane that is beyond simple transmembrane helices and forms the structural basis for assessing the extent of structural and topological rearrangements upon alphaIIb-beta3 association, i.e. integrin transmembrane signaling. | ||
==About this Structure== | ==About this Structure== | ||
2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA]. | 2K1A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1A OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Structure of the Integrin {alpha}IIb Transmembrane Segment., Lau TL, Dua V, Ulmer TS, J Biol Chem. 2008 Jun 6;283(23):16162-8. Epub 2008 Apr 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18417472 18417472] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Single-pass transmembrane segment]] | [[Category: Single-pass transmembrane segment]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:16:12 2008'' |
Revision as of 09:16, 18 June 2008
Bicelle-embedded integrin alpha(IIB) transmembrane segment
Overview
Integrin cell-adhesion receptors transduce signals bidirectionally across the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit. While the beta3 transmembrane segment consists of a linear 29-residue alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-helix (Ile-966 -Lys-989) followed by a backbone reversal that packs Phe-992-Phe-993 against the transmembrane helix. The length of the alphaIIb transmembrane helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering beta3 subunit. Sequence alignment shows Gly-991-Phe-993 to be fully conserved among all 18 human integrin alpha subunits, suggesting that their unusual structural motif is prototypical for integrin alpha subunits. The alphaIIb transmembrane structure demonstrates a level of complexity within the membrane that is beyond simple transmembrane helices and forms the structural basis for assessing the extent of structural and topological rearrangements upon alphaIIb-beta3 association, i.e. integrin transmembrane signaling.
About this Structure
2K1A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the Integrin {alpha}IIb Transmembrane Segment., Lau TL, Dua V, Ulmer TS, J Biol Chem. 2008 Jun 6;283(23):16162-8. Epub 2008 Apr 16. PMID:18417472 Page seeded by OCA on Wed Jun 18 12:16:12 2008
