1cma

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1cma" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cma, resolution 2.800&Aring;" /> '''MET REPRESSOR/DNA C...)
Next diff →

Revision as of 10:27, 20 November 2007


1cma, resolution 2.800Å

Drag the structure with the mouse to rotate

MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE

Overview

The crystal structure of the met repressor-operator complex shows two, dimeric repressor molecules bound to adjacent sites 8 base pairs apart on, an 18-base-pair DNA fragment. Sequence specificity is achieved by, insertion of double-stranded antiparallel protein beta-ribbons into the, major groove of B-form DNA, with direct hydrogen-bonding between, amino-acid side chains and the base pairs. The repressor also recognizes, sequence-dependent distortion or flexibility of the operator phosphate, backbone, conferring specificity even for inaccessible base pairs.

About this Structure

1CMA is a Single protein structure of sequence from Escherichia coli with SAM as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:1406951

Page seeded by OCA on Tue Nov 20 12:34:40 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cma"
Personal tools