1csn

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(New page: 200px<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1csn, resolution 2.0&Aring;" /> '''BINARY COMPLEX OF CAS...)
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Revision as of 10:36, 20 November 2007

Image:1csn.gif

1csn, resolution 2.0Å

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BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP

Overview

The structure of a truncated variant of casein kinase-1 from, Schizosaccharomyces pombe, has been determined in complex with MgATP at, 2.0 A resolution. The model resembles the 'closed', ATP-bound, conformations of the cyclin-dependent kinase 2 and the cAMP-dependent, protein kinase, with clear differences in the structure of surface loops, that impart unique features to casein kinase-1. The structure is of, unphosphorylated, active conformation of casein kinase-1 and the, peptide-binding site is fully accessible to substrate.

About this Structure

1CSN is a Single protein structure of sequence from Schizosaccharomyces pombe with MG, SO4 and ATP as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of casein kinase-1, a phosphate-directed protein kinase., Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X, EMBO J. 1995 Mar 1;14(5):1015-23. PMID:7889932

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