1d0h

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(New page: 200px<br /><applet load="1d0h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d0h, resolution 2.10&Aring;" /> '''THE HC FRAGMENT OF T...)
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Revision as of 10:47, 20 November 2007

Image:1d0h.gif

1d0h, resolution 2.10Å

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THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE

Overview

The entry of tetanus neurotoxin into neuronal cells proceeds through the, initial binding of the toxin to gangliosides on the cell surface. The, carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin, contains the ganglioside-binding site, which has not yet been fully, characterized. The crystal structures of native H(C) and of H(C) soaked, with carbohydrates reveal a number of binding sites and provide insight, into the possible mode of ganglioside binding.

About this Structure

1D0H is a Single protein structure of sequence from Clostridium tetani with A2G and SO4 as ligands. Full crystallographic information is available from OCA.

Reference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735

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