3bfa

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==Overview==
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{{ABSTRACT_18508083}}
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The behavior of insects and their perception of their surroundings are driven, in a large part, by odorants and pheromones. This is especially true for social insects, such as the honey bee, where the queen controls the development and the caste status of the other individuals. Pheromone perception is a complex phenomenon relying on a cascade of recognition events, initiated in antennae by pheromone recognition by a pheromone-binding protein and finishing with signal transduction at the axon membrane level. With to the objective of deciphering this initial step, we have determined the structures of the bee antennal pheromone-binding protein (ASP1) in the apo form and in complex with the main component of the queen mandibular pheromonal mixture, 9-keto-2(E)-decenoic acid (9-ODA) and with nonpheromonal components. In the apo protein, the C terminus obstructs the binding site. In contrast, ASP1 complexes have different open conformations, depending on the ligand shape, leading to different volumes of the binding cavity. The binding site integrity depends on the C terminus (111-119) conformation, which involves the interplay of two factors; i.e. the presence of a ligand and a low pH. Ligand binding to ASP1 is favored by low pH, opposite to what is observed with other pheromone-binding proteins, such as those of Bombyx mori and Anopheles gambiae.
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==About this Structure==
==About this Structure==
3BFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFA OCA].
3BFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFA OCA].
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==Reference==
 
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Structural Basis of the Honey Bee PBP Pheromone and pH-induced Conformational Change., Pesenti ME, Spinelli S, Bezirard V, Briand L, Pernollet JC, Tegoni M, Cambillau C, J Mol Biol. 2008 Apr 27;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18508083 18508083]
 
[[Category: Apis mellifera]]
[[Category: Apis mellifera]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 15:11:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 18:43:21 2008''

Revision as of 15:43, 25 June 2008

Image:3bfa.png

Template:STRUCTURE 3bfa

Crystal structure of a pheromone binding protein from Apis mellifera in complex with the Queen mandibular pheromone


Template:ABSTRACT 18508083

About this Structure

3BFA is a Single protein structure of sequence from Apis mellifera. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 18:43:21 2008

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