1nth

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[[Image:1nth.gif|left|200px]]
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[[Image:1nth.png|left|200px]]
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==Overview==
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{{ABSTRACT_12029132}}
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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==About this Structure==
==About this Structure==
1NTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l2r 1l2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA].
1NTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1l2r 1l2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTH OCA].
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==Reference==
 
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A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12029132 12029132]
 
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:57:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 19:20:29 2008''

Revision as of 16:20, 25 June 2008

Image:1nth.png

Template:STRUCTURE 1nth

Crystal structure of the methanosarcina barkeri monomethylamine methyltransferase (MTMB)


Template:ABSTRACT 12029132

About this Structure

1NTH is a Single protein structure of sequence from Methanosarcina barkeri. This structure supersedes the now removed PDB entry 1l2r. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 19:20:29 2008

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