1a0i

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[[Image:1a0i.gif|left|200px]]
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[[Image:1a0i.png|left|200px]]
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==Overview==
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{{ABSTRACT_8653795}}
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The crystal structure of the ATP-dependent DNA ligase from bacteriophage T7 has been solved at 2.6 A resolution. The protein comprises two domains with a deep cleft running between them. The structure of a complex with ATP reveals that the nucleotide binding pocket is situated on the larger N-terminal domain, at the base of the cleft between the two domains of the enzyme. Comparison of the overall domain structure with that of DNA methyltransferases, coupled with other evidence, suggests that DNA also binds in this cleft. Since this structure is the first of the nucleotidyltransferase superfamily, which includes the eukaryotic mRNA capping enzymes, the relationship between the structure of DNA ligase and that of other nucleotidyltransferases is also discussed.
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==About this Structure==
==About this Structure==
1A0I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. The following page contains interesting information on the relation of 1A0I with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb55_1.html DNA Ligase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0I OCA].
1A0I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. The following page contains interesting information on the relation of 1A0I with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb55_1.html DNA Ligase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0I OCA].
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==Reference==
 
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Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7., Subramanya HS, Doherty AJ, Ashford SR, Wigley DB, Cell. 1996 May 17;85(4):607-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8653795 8653795]
 
[[Category: DNA Ligase]]
[[Category: DNA Ligase]]
[[Category: Enterobacteria phage t7]]
[[Category: Enterobacteria phage t7]]
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[[Category: Dna replication]]
[[Category: Dna replication]]
[[Category: Ligase]]
[[Category: Ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:37:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:01:33 2008''

Revision as of 14:01, 26 June 2008

Image:1a0i.png

Template:STRUCTURE 1a0i

ATP-DEPENDENT DNA LIGASE FROM BACTERIOPHAGE T7 COMPLEX WITH ATP


Template:ABSTRACT 8653795

About this Structure

1A0I is a Single protein structure of sequence from Enterobacteria phage t7. The following page contains interesting information on the relation of 1A0I with [DNA Ligase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:01:33 2008

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