1bpo

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[[Image:1bpo.gif|left|200px]]
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[[Image:1bpo.png|left|200px]]
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==Overview==
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{{ABSTRACT_9827808}}
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Clathrin triskelions form the lattice that organizes recruitment of proteins to coated pits and helps drive vesiculation of the lipid bilayer. We report the crystal structure at 2.6 A resolution of a 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain. The structure comprises the globular "terminal domain" and the linker that joins it to the end of a triskelion leg. The terminal domain is a seven-blade beta propeller, a structure well adapted to interaction with multiple partners, such as the AP-1 and AP-2 sorting adaptor complexes and the nonvisual arrestins. The linker is an alpha-helical zigzag emanating from the propeller domain. We propose that this simple motif may extend into the rest of the clathrin leg.
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==About this Structure==
==About this Structure==
1BPO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 1BPO with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPO OCA].
1BPO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 1BPO with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPO OCA].
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==Reference==
 
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Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker., ter Haar E, Musacchio A, Harrison SC, Kirchhausen T, Cell. 1998 Nov 13;95(4):563-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9827808 9827808]
 
[[Category: Clathrin]]
[[Category: Clathrin]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Musacchio, A.]]
[[Category: Musacchio, A.]]
[[Category: Clathrin endocytosis beta-propeller coated-pit]]
[[Category: Clathrin endocytosis beta-propeller coated-pit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:48:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:05:43 2008''

Revision as of 14:05, 26 June 2008

Image:1bpo.png

Template:STRUCTURE 1bpo

CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER


Template:ABSTRACT 9827808

About this Structure

1BPO is a Single protein structure of sequence from Rattus norvegicus. The following page contains interesting information on the relation of 1BPO with [Clathrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:05:43 2008

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