1br1

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[[Image:1br1.gif|left|200px]]
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[[Image:1br1.png|left|200px]]
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==Overview==
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{{ABSTRACT_9741621}}
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The crystal structures of an expressed vertebrate smooth muscle myosin motor domain (MD) and a motor domain-essential light chain (ELC) complex (MDE), both with a transition state analog (MgADP x AIF4-) in the active site, have been determined to 2.9 A and 3.5 A resolution, respectively. The MDE structure with an ATP analog (MgADP x BeFx) was also determined to 3.6 A resolution. In all three structures, a domain of the C-terminal region, the "converter," is rotated approximately 70 degrees from that in nucleotide-free skeletal subfragment 1 (S1). We have found that the MDE-BeFx and MDE-AIF4- structures are almost identical, consistent with the fact that they both bind weakly to actin. A comparison of the lever arm positions in MDE-AIF4- and in nucleotide-free skeletal S1 shows that a potential displacement of approximately 10 nm can be achieved during the power stroke.
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==About this Structure==
==About this Structure==
1BR1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. The following page contains interesting information on the relation of 1BR1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb18_1.html Myosin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR1 OCA].
1BR1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. The following page contains interesting information on the relation of 1BR1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb18_1.html Myosin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR1 OCA].
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==Reference==
 
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Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state., Dominguez R, Freyzon Y, Trybus KM, Cohen C, Cell. 1998 Sep 4;94(5):559-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9741621 9741621]
 
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Myosin]]
[[Category: Myosin]]
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[[Category: Trybus, K M.]]
[[Category: Trybus, K M.]]
[[Category: Muscle protein]]
[[Category: Muscle protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:05:51 2008''

Revision as of 14:05, 26 June 2008

Image:1br1.png

Template:STRUCTURE 1br1

SMOOTH MUSCLE MYOSIN MOTOR DOMAIN-ESSENTIAL LIGHT CHAIN COMPLEX WITH MGADP.ALF4 BOUND AT THE ACTIVE SITE


Template:ABSTRACT 9741621

About this Structure

1BR1 is a Protein complex structure of sequences from Gallus gallus. The following page contains interesting information on the relation of 1BR1 with [Myosin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:05:51 2008

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