1buw

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[[Image:1buw.jpg|left|200px]]
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[[Image:1buw.png|left|200px]]
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==Overview==
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{{ABSTRACT_9843411}}
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Although numerous reports have documented that the S-nitrosylation of cysteine residues by NO alters the activities of a wide variety of proteins, the direct visualization and the structural consequences of this reversible modification have not yet been reported for any protein. Here we describe the crystal structure of S-nitroso-nitrosylhemoglobin determined at a resolution of 1.8 A. The specific reaction of NO with Cys93beta is confirmed in this structure, and a large S-nitrosylation-induced change in the tertiary structure of the COOH-terminal dipeptides of the beta subunits provides additional insight into the stereochemical mechanism by which blood flow is regulated by the interaction of NO with hemoglobin.
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==About this Structure==
==About this Structure==
1BUW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1BUW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html Hemoglobin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUW OCA].
1BUW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1BUW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html Hemoglobin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUW OCA].
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==Reference==
 
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Crystal structure of the S-nitroso form of liganded human hemoglobin., Chan NL, Rogers PH, Arnone A, Biochemistry. 1998 Nov 24;37(47):16459-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9843411 9843411]
 
[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Rogers, P H.]]
[[Category: Rogers, P H.]]
[[Category: Oxygen transport and vasodilation]]
[[Category: Oxygen transport and vasodilation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:58:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:06:07 2008''

Revision as of 14:06, 26 June 2008

Image:1buw.png

Template:STRUCTURE 1buw

CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A


Template:ABSTRACT 9843411

About this Structure

1BUW is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1BUW with [Hemoglobin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:06:07 2008

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