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1c1e

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[[Image:1c1e.jpg|left|200px]]
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[[Image:1c1e.png|left|200px]]
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==Overview==
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{{ABSTRACT_10600746}}
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The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.
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==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
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==Reference==
 
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Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600746 10600746]
 
[[Category: Antibodies]]
[[Category: Antibodies]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: Diels-alder]]
[[Category: Diels-alder]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:12:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:06:22 2008''

Revision as of 14:06, 26 June 2008

Image:1c1e.png

Template:STRUCTURE 1c1e

CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN


Template:ABSTRACT 10600746

About this Structure

The following page contains interesting information on the relation of 1C1E with [Antibodies]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:06:22 2008

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