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1cjw

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[[Image:1cjw.gif|left|200px]]
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[[Image:1cjw.png|left|200px]]
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==Overview==
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{{ABSTRACT_10319816}}
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Serotonin N-acetyltransferase, a member of the GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to melatonin, the circadian neurohormone. Comparison of the structures of the substrate-free enzyme and the complex with a bisubstrate analog, coenzyme A-S-acetyltryptamine, demonstrates that acetyl coenzyme A (AcCoA) binding is accompanied by a large conformational change that in turn leads to the formation of the serotonin-binding site. The structure of the complex also provides insight into how the enzyme may facilitate acetyl transfer. A water-filled channel leading from the active site to the surface provides a pathway for proton removal following amine deprotonation. Furthermore, structural and mutagenesis results indicate an important role for Tyr-168 in catalysis.
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==About this Structure==
==About this Structure==
1CJW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJW OCA].
1CJW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CJW OCA].
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==Reference==
 
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The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog., Hickman AB, Namboodiri MA, Klein DC, Dyda F, Cell. 1999 Apr 30;97(3):361-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10319816 10319816]
 
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Namboodiri, M A.A.]]
[[Category: Namboodiri, M A.A.]]
[[Category: N-acetyl transferase]]
[[Category: N-acetyl transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:48:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:08:22 2008''

Revision as of 14:08, 26 June 2008

Image:1cjw.png

Template:STRUCTURE 1cjw

SEROTONIN N-ACETYLTRANFERASE COMPLEXED WITH A BISUBSTRATE ANALOG


Template:ABSTRACT 10319816

About this Structure

1CJW is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:08:22 2008

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