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1cos

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[[Image:1cos.jpg|left|200px]]
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==Overview==
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{{ABSTRACT_8446897}}
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The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.
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==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA].
The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA].
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==Reference==
 
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Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8446897 8446897]
 
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
[[Category: Cascio, D.]]
[[Category: Cascio, D.]]
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[[Category: Mcrorie, D K.]]
[[Category: Mcrorie, D K.]]
[[Category: Alpha-helical bundle]]
[[Category: Alpha-helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:57:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:08:58 2008''

Revision as of 14:08, 26 June 2008

Image:1cos.png

Template:STRUCTURE 1cos

CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE


Template:ABSTRACT 8446897

About this Structure

The following page contains interesting information on the relation of 1COS with [Designer Proteins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:08:58 2008

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