1d2n

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[[Image:1d2n.gif|left|200px]]
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==Overview==
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{{ABSTRACT_9727495}}
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N-ethylmaleimide-sensitive fusion protein (NSF) is a cytosolic ATPase required for many intracellular vesicle fusion reactions. NSF consists of an amino-terminal region that interacts with other components of the vesicle trafficking machinery, followed by two homologous ATP-binding cassettes, designated D1 and D2, that possess essential ATPase and hexamerization activities, respectively. The crystal structure of D2 bound to Mg2+-AMPPNP has been determined at 1.75 A resolution. The structure consists of a nucleotide-binding and a helical domain, and it is unexpectedly similar to the first two domains of the clamp-loading subunit delta' of E. coli DNA polymerase III. The structure suggests several regions responsible for coupling of ATP hydrolysis to structural changes in full-length NSF.
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==About this Structure==
==About this Structure==
1D2N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. The following page contains interesting information on the relation of 1D2N with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2N OCA].
1D2N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. The following page contains interesting information on the relation of 1D2N with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2N OCA].
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==Reference==
 
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Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein., Lenzen CU, Steinmann D, Whiteheart SW, Weis WI, Cell. 1998 Aug 21;94(4):525-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9727495 9727495]
 
[[Category: AAA+ Proteases]]
[[Category: AAA+ Proteases]]
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: Hexamerization domain]]
[[Category: Hexamerization domain]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:22:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:09:32 2008''

Revision as of 14:09, 26 June 2008

Image:1d2n.png

Template:STRUCTURE 1d2n

D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN


Template:ABSTRACT 9727495

About this Structure

1D2N is a Single protein structure of sequence from Cricetulus griseus. The following page contains interesting information on the relation of 1D2N with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:09:32 2008

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