1dgi

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[[Image:1dgi.gif|left|200px]]
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==Overview==
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{{ABSTRACT_10618374}}
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The structure of the extracellular, three-domain poliovirus receptor (CD155) complexed with poliovirus (serotype 1) has been determined to 22-A resolution by means of cryo-electron microscopy and three-dimensional image-reconstruction techniques. Density corresponding to the receptor was isolated in a difference electron density map and fitted with known structures, homologous to those of the three individual CD155 Ig-like domains. The fit was confirmed by the location of carbohydrate moieties in the CD155 glycoprotein, the conserved properties of elbow angles in the structures of cell surface molecules with Ig-like folds, and the concordance with prior results of CD155 and poliovirus mutagenesis. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. However, the orientation of the long, slender CD155 molecule relative to the poliovirus surface is quite different from the orientation of intercellular adhesion molecule-1 on rhinoviruses. In addition, the residues that provide specificity of recognition differ for the two receptors. The principal feature of receptor binding common to these two picornaviruses is the site in the canyon at which binding occurs. This site may be a trigger for initiation of the subsequent uncoating step required for viral infection.
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==About this Structure==
==About this Structure==
1DGI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_poliovirus_1 Human poliovirus 1]. The following page contains interesting information on the relation of 1DGI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGI OCA].
1DGI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_poliovirus_1 Human poliovirus 1]. The following page contains interesting information on the relation of 1DGI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGI OCA].
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==Reference==
 
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Interaction of the poliovirus receptor with poliovirus., He Y, Bowman VD, Mueller S, Bator CM, Bella J, Peng X, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):79-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10618374 10618374]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human poliovirus 1]]
[[Category: Human poliovirus 1]]
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[[Category: Poliovirus-receptor complex]]
[[Category: Poliovirus-receptor complex]]
[[Category: Pvr]]
[[Category: Pvr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:50:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:10:23 2008''

Revision as of 14:10, 26 June 2008

Image:1dgi.png

Template:STRUCTURE 1dgi

Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155


Template:ABSTRACT 10618374

About this Structure

1DGI is a Protein complex structure of sequences from Homo sapiens and Human poliovirus 1. The following page contains interesting information on the relation of 1DGI with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:10:23 2008

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