1dlh

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[[Image:1dlh.gif|left|200px]]
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[[Image:1dlh.png|left|200px]]
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==Overview==
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{{ABSTRACT_8145819}}
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An influenza virus peptide binds to HLA-DR1 in an extended conformation with a pronounced twist. Thirty-five per cent of the peptide surface is accessible to solvent and potentially available for interaction with the antigen receptor on T cells. Pockets in the peptide-binding site accommodate five of the thirteen side chains of the bound peptide, and explain the peptide specificity of HLA-DR1. Twelve hydrogen bonds between conserved HLA-DR1 residues and the main chain of the peptide provide a universal mode of peptide binding, distinct from the strategy used by class I histocompatibility proteins.
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==About this Structure==
==About this Structure==
1DLH is a [[Protein complex]] structure. The following page contains interesting information on the relation of 1DLH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLH OCA].
1DLH is a [[Protein complex]] structure. The following page contains interesting information on the relation of 1DLH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLH OCA].
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==Reference==
 
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Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide., Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, Strominger JL, Wiley DC, Nature. 1994 Mar 17;368(6468):215-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8145819 8145819]
 
[[Category: Major Histocompatibility Complex]]
[[Category: Major Histocompatibility Complex]]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Stern, L J.]]
[[Category: Stern, L J.]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:59:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:11:09 2008''

Revision as of 14:11, 26 June 2008

Image:1dlh.png

Template:STRUCTURE 1dlh

CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE


Template:ABSTRACT 8145819

About this Structure

1DLH is a Protein complex structure. The following page contains interesting information on the relation of 1DLH with [Major Histocompatibility Complex]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:11:09 2008

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