1g3i

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[[Image:1g3i.gif|left|200px]]
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[[Image:1g3i.png|left|200px]]
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==Overview==
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{{ABSTRACT_11106733}}
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HslUV is a "prokaryotic proteasome" composed of the HslV protease and the HslU ATPase, a chaperone of the Clp/Hsp100 family. The 3.4 A crystal structure of an HslUV complex is presented here. Two hexameric ATP binding rings of HslU bind intimately to opposite sides of the HslV protease; the HslU "intermediate domains" extend outward from the complex. The solution structure of HslUV, derived from small angle X-ray scattering data under conditions where the complex is assembled and active, agrees with this crystallographic structure. When the complex forms, the carboxy-terminal helices of HslU distend and bind between subunits of HslV, and the apical helices of HslV shift substantially, transmitting a conformational change to the active site region of the protease.
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==About this Structure==
==About this Structure==
1G3I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. The following page contains interesting information on the relation of 1G3I with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3I OCA].
1G3I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. The following page contains interesting information on the relation of 1G3I with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3I OCA].
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==Reference==
 
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Crystal and solution structures of an HslUV protease-chaperone complex., Sousa MC, Trame CB, Tsuruta H, Wilbanks SM, Reddy VS, McKay DB, Cell. 2000 Nov 10;103(4):633-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11106733 11106733]
 
[[Category: AAA+ Proteases]]
[[Category: AAA+ Proteases]]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Wilbanks, S M.]]
[[Category: Wilbanks, S M.]]
[[Category: Chaperone/hydrolase]]
[[Category: Chaperone/hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:05:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:24:27 2008''

Revision as of 14:24, 26 June 2008

Image:1g3i.png

Template:STRUCTURE 1g3i

CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX


Template:ABSTRACT 11106733

About this Structure

1G3I is a Protein complex structure of sequences from Haemophilus influenzae. The following page contains interesting information on the relation of 1G3I with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:24:27 2008

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