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1i7x

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[[Image:1i7x.gif|left|200px]]
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[[Image:1i7x.png|left|200px]]
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==Overview==
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{{ABSTRACT_11348595}}
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As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.
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==About this Structure==
==About this Structure==
1I7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].
1I7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].
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==Reference==
 
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The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11348595 11348595]
 
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Extended interface]]
[[Category: Extended interface]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:41:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:32:01 2008''

Revision as of 14:32, 26 June 2008

Image:1i7x.png

Template:STRUCTURE 1i7x

BETA-CATENIN/E-CADHERIN COMPLEX


Template:ABSTRACT 11348595

About this Structure

1I7X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:32:01 2008

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