1k5j

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[[Image:1k5j.gif|left|200px]]
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[[Image:1k5j.png|left|200px]]
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==Overview==
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{{ABSTRACT_11684019}}
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The efficient assembly of histone complexes and nucleosomes requires the participation of molecular chaperones. Currently, there is a paucity of data on their mechanism of action. We now present the structure of an N-terminal domain of nucleoplasmin (Np-core) at 2.3 A resolution. The Np-core monomer is an eight-stranded beta barrel that fits snugly within a stable pentamer. In the crystal, two pentamers associate to form a decamer. We show that both Np and Np-core are competent to assemble large complexes that contain the four core histones. Further experiments and modeling suggest that these complexes each contain five histone octamers which dock to a central Np decamer. This work has important ramifications for models of histone storage, sperm chromatin decondensation, and nucleosome assembly.
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==About this Structure==
==About this Structure==
1K5J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1K5J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb85_1.html Importins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5J OCA].
1K5J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1K5J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb85_1.html Importins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5J OCA].
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==Reference==
 
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The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly., Dutta S, Akey IV, Dingwall C, Hartman KL, Laue T, Nolte RT, Head JF, Akey CW, Mol Cell. 2001 Oct;8(4):841-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11684019 11684019]
 
[[Category: Importins]]
[[Category: Importins]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Jellyroll]]
[[Category: Jellyroll]]
[[Category: Pentamer]]
[[Category: Pentamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:20:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:37:16 2008''

Revision as of 14:37, 26 June 2008

Template:STRUCTURE 1k5j

The Crystal Structure of Nucleoplasmin-Core


Template:ABSTRACT 11684019

About this Structure

1K5J is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1K5J with [Importins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:37:16 2008

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