1k83

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[[Image:1k83.gif|left|200px]]
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[[Image:1k83.png|left|200px]]
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==Overview==
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{{ABSTRACT_11805306}}
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The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
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==About this Structure==
==About this Structure==
1K83 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1K83 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K83 OCA].
1K83 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1K83 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K83 OCA].
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==Reference==
 
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Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11805306 11805306]
 
[[Category: Amanita phalloides]]
[[Category: Amanita phalloides]]
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Zinc motif]]
[[Category: Zinc motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:25:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:37:30 2008''

Revision as of 14:37, 26 June 2008

Template:STRUCTURE 1k83

Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin


Template:ABSTRACT 11805306

About this Structure

1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:37:30 2008

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