1kyo

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[[Image:1kyo.gif|left|200px]]
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==Overview==
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{{ABSTRACT_11880631}}
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Small diffusible redox proteins facilitate electron transfer in respiration and photosynthesis by alternately binding to integral membrane proteins. Specific and transient complexes need to be formed between the redox partners to ensure fast turnover. In respiration, the mobile electron carrier cytochrome c shuttles electrons from the cytochrome bc1 complex to cytochrome c oxidase. Despite extensive studies of this fundamental step of energy metabolism, the structures of the respective electron transfer complexes were not known. Here we present the crystal structure of the complex between cytochrome c and the cytochrome bc1 complex from Saccharomyces cerevisiae. The complex was crystallized with the help of an antibody fragment, and its structure was determined at 2.97-A resolution. Cytochrome c is bound to subunit cytochrome c1 of the enzyme. The tight and specific interactions critical for electron transfer are mediated mainly by nonpolar forces. The close spatial arrangement of the c-type hemes unexpectedly suggests a direct and rapid heme-to-heme electron transfer at a calculated rate of up to 8.3 x 10(6) s(-1). Remarkably, cytochrome c binds to only one recognition site of the homodimeric multisubunit complex. Interestingly, the occupancy of quinone in the Qi site is higher in the monomer with bound cytochrome c, suggesting a coordinated binding and reduction of both electron-accepting substrates. Obviously, cytochrome c reduction by the cytochrome bc1 complex can be regulated in response to respiratory conditions.
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==About this Structure==
==About this Structure==
1KYO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1KYO with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb36_1.html Cytochrome c]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KYO OCA].
1KYO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1KYO with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb36_1.html Cytochrome c]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KYO OCA].
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==Reference==
 
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Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c., Lange C, Hunte C, Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2800-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11880631 11880631]
 
[[Category: Cytochrome c]]
[[Category: Cytochrome c]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Enzyme substrate complex]]
[[Category: Enzyme substrate complex]]
[[Category: Multisubunit membrane protein complex]]
[[Category: Multisubunit membrane protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:19:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:39:13 2008''

Revision as of 14:39, 26 June 2008

Image:1kyo.png


PDB ID 1kyo

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1kyo, resolution 2.97Å ()
Ligands: , ,
Non-Standard Residues:
Activity: Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2
Related: 1ezv, 1kb9
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



YEAST CYTOCHROME BC1 COMPLEX WITH BOUND SUBSTRATE CYTOCHROME C


Template:ABSTRACT 11880631

About this Structure

1KYO is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1KYO with [Cytochrome c]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:39:13 2008

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