1dgm

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Revision as of 11:09, 20 November 2007

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spinqualitylabelsall models 1dgm, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF ADENOSINE KINASE FROM TOXOPLASMA GONDII

Overview

Human infection with Toxoplasma gondii is an important cause of morbidity, and mortality. Protozoan parasites such as T. gondii are incapable of de, novo purine biosynthesis and must acquire purines from their host, so the, purine salvage pathway offers a number of potential targets for, antiparasitic chemotherapy. In T. gondii tachyzoites, adenosine is the, predominantly salvaged purine nucleoside, and thus adenosine kinase is a, key enzyme in the purine salvage pathway of this parasite. The structure, of T. gondii adenosine kinase was solved using molecular replacement and, refined by simulated annealing at 1.8 A resolution to an R-factor of, 0.214. The overall structure and the active site geometry are similar to, human adenosine kinase, although there are significant differences. The T., gondii adenosine kinase has several unique features compared to the human, sequence, including a five-residue deletion in one of the four linking, segments between the two domains, which is probably responsible for a, major change in the orientation of the two domains with respect to each, other. These structural differences suggest the possibility of developing, specific inhibitors of the parasitic enzyme.

About this Structure

1DGM is a Single protein structure of sequence from Toxoplasma gondii with MG, CL, ADN and ACY as ligands. Active as Adenosine kinase, with EC number 2.7.1.20 Full crystallographic information is available from OCA.

Reference

Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 A resolution., Cook WJ, DeLucas LJ, Chattopadhyay D, Protein Sci. 2000 Apr;9(4):704-12. PMID:10794412

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