1l3w

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[[Image:1l3w.gif|left|200px]]
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[[Image:1l3w.png|left|200px]]
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==Overview==
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{{ABSTRACT_11964443}}
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Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin, a representative "classical" cadherin. The structure suggests a molecular mechanism for adhesion between cells by classical cadherins, and it provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) cadherin interactions. The trans adhesive interface is a twofold symmetric interaction defined by a conserved tryptophan side chain at the membrane-distal end of a cadherin molecule from one cell, which inserts into a hydrophobic pocket at the membrane-distal end of a cadherin molecule from the opposing cell.
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==About this Structure==
==About this Structure==
1L3W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3W OCA].
1L3W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3W OCA].
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==Reference==
 
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C-cadherin ectodomain structure and implications for cell adhesion mechanisms., Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L, Science. 2002 May 17;296(5571):1308-13. Epub 2002 Apr 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11964443 11964443]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Ectodomain]]
[[Category: Ectodomain]]
[[Category: Extracellular]]
[[Category: Extracellular]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:30:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:40:22 2008''

Revision as of 14:40, 26 June 2008

Image:1l3w.png

Template:STRUCTURE 1l3w

C-cadherin Ectodomain


Template:ABSTRACT 11964443

About this Structure

1L3W is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:40:22 2008

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