1mlw

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[[Image:1mlw.gif|left|200px]]
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[[Image:1mlw.png|left|200px]]
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==Overview==
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{{ABSTRACT_12379098}}
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Tryptophan hydroxylase oxidizes L-tryptophan to 5-hydroxy-L-tryptophan in the rate-determining step of serotonin biosynthesis. We have determined the X-ray crystal structure (1.7 A) of a truncated functional form of human tryptophan hydroxylase with the bound cofactor analogue 7,8-dihydro-L-biopterin, providing the first atomic-resolution information for the catalytic domain of this important enzyme. Comparison of the three-dimensional structures of all three members of the aromatic amino acid hydroxylase family--tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase--reveals important differences at the active sites.
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==About this Structure==
==About this Structure==
1MLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1MLW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA].
1MLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1MLW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA].
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==Reference==
 
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Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin., Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC, Biochemistry. 2002 Oct 22;41(42):12569-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12379098 12379098]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine Hydroxylase]]
[[Category: Phenylalanine Hydroxylase]]
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[[Category: Wang, L.]]
[[Category: Wang, L.]]
[[Category: Aromatic amino acid hydroxylase catalytic domain fold]]
[[Category: Aromatic amino acid hydroxylase catalytic domain fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:23:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:42:55 2008''

Revision as of 14:42, 26 June 2008

Template:STRUCTURE 1mlw

Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)


Template:ABSTRACT 12379098

About this Structure

1MLW is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1MLW with [Phenylalanine Hydroxylase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:42:55 2008

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