1o9j

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==Overview==
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{{ABSTRACT_12693930}}
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Eta-crystallin is a retinal dehydrogenase that has acquired a role as a structural protein in the eye lens of elephant shrews, members of an ancient order of mammals. While it retains some activity toward retinal, which is oxidized to retinoic acid, the protein has acquired a number of specific sequence changes that have presumably been selected to enhance the lens role. The crystal structure of eta-crystallin, in common with class 1 and 2 ALDHs, is a dimer of dimers. It has a better-defined NAD binding site than those of related mammalian ALDH1 enzymes with the cofactor bound in the "hydride transfer" position in all four monomers with small differences about the dimer dyads. Although the active site is well conserved, the substrate-binding site is larger in eta-crystallin, and there are some mutations to the substrate access tunnel that might affect binding or release of substrate and product. It is possible that eta-crystallin has lost flexibility to improve its role in the lens. Enhanced binding of cofactor could enable it to act as a UV/blue light filter in the lens, improving visual acuity. The structure not only gives a view of a "natural mutant" of ALDH1 illustrating the adaptive conflict that can arise in multifunctional proteins, but also provides a well-ordered NAD binding site structure for this class of enzymes with important roles in development and health.
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==About this Structure==
==About this Structure==
1O9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Elephantulus_edwardii Elephantulus edwardii]. The following page contains interesting information on the relation of 1O9J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9J OCA].
1O9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Elephantulus_edwardii Elephantulus edwardii]. The following page contains interesting information on the relation of 1O9J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9J OCA].
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==Reference==
 
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Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens., Bateman OA, Purkiss AG, van Montfort R, Slingsby C, Graham C, Wistow G, Biochemistry. 2003 Apr 22;42(15):4349-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12693930 12693930]
 
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Elephantulus edwardii]]
[[Category: Elephantulus edwardii]]
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[[Category: Eye-lens protein]]
[[Category: Eye-lens protein]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:33:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:46:20 2008''

Revision as of 14:46, 26 June 2008

Image:1o9j.png

Template:STRUCTURE 1o9j

THE X-RAY CRYSTAL STRUCTURE OF ETA-CRYSTALLIN


Template:ABSTRACT 12693930

About this Structure

1O9J is a Single protein structure of sequence from Elephantulus edwardii. The following page contains interesting information on the relation of 1O9J with [Aconitase and Iron Regulatory Protein 1]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:46:20 2008

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