1psi

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[[Image:1psi.gif|left|200px]]
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[[Image:1psi.png|left|200px]]
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==Overview==
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{{ABSTRACT_8756325}}
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The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matching that found in all other families of serine proteinase inhibitors. This unexpected finding in the absence of loop insertion into the body of the molecule favours a two-stage mechanism of inhibition and provides a model for the heparin activation of antithrombin. The beta-pleated strand conformation of the loop also accounts for the polymerization of the serpins in disease and for their association with other beta-sheet structures, most notably the beta-amyloid of Alzheimer's disease.
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==About this Structure==
==About this Structure==
1PSI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PSI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb53_1.html Serpins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSI OCA].
1PSI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PSI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb53_1.html Serpins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSI OCA].
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==Reference==
 
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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin., Elliott PR, Lomas DA, Carrell RW, Abrahams JP, Nat Struct Biol. 1996 Aug;3(8):676-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8756325 8756325]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Serpins]]
[[Category: Serpins]]
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[[Category: Serpin]]
[[Category: Serpin]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:26:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:50:15 2008''

Revision as of 14:50, 26 June 2008

Image:1psi.png

Template:STRUCTURE 1psi

INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU


Template:ABSTRACT 8756325

About this Structure

1PSI is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1PSI with [Serpins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:50:15 2008

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