1r7r

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[[Image:1r7r.gif|left|200px]]
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[[Image:1r7r.png|left|200px]]
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==Overview==
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{{ABSTRACT_14643202}}
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p97/VCP is a member of the AAA ATPase family and has roles in both membrane fusion and ubiquitin dependent protein degradation. Here, we present a 3.6A crystal structure of murine p97 in which D2 domain has been modelled as poly-alanine and the remaining approximately 100 residues are absent. The resulting structure illustrates a head-to-tail packing arrangement of the two p97 AAA domains in a natural hexameric state with D1 ADP bound and D2 nucleotide free. The head-to-tail packing arrangement observed in this structure is in contrast to our previously predicted tail-to-tail packing model. The linker between the D1 and D2 domains is partially disordered, suggesting a flexible nature. Normal mode analysis of the crystal structure suggests anti-correlated motions and distinct conformational states of the two AAA domains.
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==About this Structure==
==About this Structure==
1R7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1R7R with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7R OCA].
1R7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1R7R with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA+ Proteases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7R OCA].
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==Reference==
 
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The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14643202 14643202]
 
[[Category: AAA+ Proteases]]
[[Category: AAA+ Proteases]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: P97]]
[[Category: P97]]
[[Category: Vcp]]
[[Category: Vcp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:11:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:53:58 2008''

Revision as of 14:53, 26 June 2008

Image:1r7r.png

Template:STRUCTURE 1r7r

The crystal structure of murine p97/VCP at 3.6A


Template:ABSTRACT 14643202

About this Structure

1R7R is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1R7R with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:53:58 2008

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